Author: Phillip J. Gregory, PharmD
Summary: Several clinical trials have evaluated the use of D-mannose supplements for UTI.
Findings: The evidence for D-mannose is consistently positive for reducing UTI recurrence rates, and D-mannose was found to be comparable to nitrofurantoin (antibiotic) in the largest study to date. Preliminary data also suggest that D-mannose can reduce symptoms of an acute UTI. Certainly, more and higher-quality data are desirable to validate the findings to date. On the basis of the evidence so far, however, D-mannose is a reasonable option to consider for UTI prevention in women with recurrent UTI. It is safe, well tolerated, and relatively inexpensive.
Author: Debra Rose Wilson PhD, MSN, RN, IBCLC, AHN-BC, CHT
Summary: More research needs to be done, but D-mannose appears to be a promising nutritional supplement that may be an option for treating and preventing UTIs, especially in people who have frequent UTIs. Most people who take it don’t experience any side effects.
Headline: D-Mannose: An Effective Urinary Tract Infection Treatment
The Stats: A study of nearly 200 female college students presenting with symptoms of UTI found that more than 40% of infections were resistant to first- and second- line antibiotics.
Observations: D-mannose, a natural supplement for urinary tract infections, has been shown to block E coli receptors effectively and literally flush bacteria away. D-mannose has also been found to slow recurrence of UTI.
Conclusions: For those with UTIs that would otherwise be treated with antibiotics, D-mannose may be one of many first steps in the war against antibiotic resistance.
Headline: D-mannose: a promising support for acute urinary tract infections in women.
Study Stats: 45 women evaluated over a 15 month period to determine whether D-mannose alone is effective in treating acute urinary tract infections in women and its possible use in managing recurrences. (Domenici and colleagues)
Results: D-mannose had a significant positive effect on resolving UTI's and improving patients' quality of life. As a preventative administered for 6 months, it also showed promising results.
Study Stats: Clinical trial conducted among 308 women comparing D-Mannose to the antibiotic Nitrofurantoin for effectiveness in preventing recurring UTI's. ( Kranjčec and colleagues)
Results: D-Mannose had the lowest percentage of recurrence and significantly lower risk of side effects compared to the antibiotic.
In July 2018, we surveyed over 1,000 women across the US and found out that 68% suffer from UTI's on an occasional or regular basis. That's about 83 million women. All age groups were equally affected.
And 88% are unaware that there's a natural nutritional supplement that can help alleviate UTI symptoms and prevent recurrences.
"I would consider it because it is a more natural approach"
"If it works and is easy to use, yes, I would try it"
"Sounds like a product that can help without taking antibiotics"
"I would likely try it to decrease my chances of getting UTI’s"
"I prefer natural products to pharmaceuticals"
"If OTC, it can resolve the problem without waiting for a doctor appointment and having a co-pay"
"I DON'T LIKE ANTIBIOTICS, THEY CAUSE OTHER PROBLEMS"
"I am a trained homeopath and always prefer more natural solutions"
"Less side effects"
"Purity of product. I use alternative medicine to clear up problems"
"Over the counter, no Dr appt."
"Don’t like to take medication if not needed"
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